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KMID : 0617220000110010135
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Duksung Bulletin Phamaceutical Sciences
2000 Volume.11 No. 1 p.135 ~ p.143
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Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry
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Myung, Seung-Woon
Chang, Yoon-Jung/Kim, Hye-Ki/Kim, Dong-Hyun/Kim, Myungsoo/Kang, TaeKyung/Yoo, Eun-Ah
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Abstract
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Using the high performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/APCI-MS/MS) technique, together with established trends from the literature. the structures of metabolites and impurities of amiodarone, an anti-arhythmic drug, have been assigned. By comparing analyses of products of incubation with rat liver microsomes with controls in which glucose 6-phosphate dehydrogenase was omitted, metabolites could be distinguished from impurities. Structures for the two proposed metabolites and four impurities are proposed. Copyright ⓒ 2000 John Wiley ＆ Sons, Ltd.
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